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12th Biology 2013 Set2 Delhi Board Paper Solution

Question 9

Describe the gene therapy procedure for an ADA-deficient patient.

Answer
In gene therapy, lymphocytes from the blood of patient are grown in a culture ouside the body. A functional ADA CDNA (using reteroviral vector) is then introduced into these lymphocytes which are subsequently returned to the patient.
 
However as these cells are not immortal, patient requires periodic infusions of such genetically engineered lymphocytes.